nstp-4 UDP-N-acetylglucosamine/UDP-N-acetylgalactosaminetransporter nstp-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nstp-4
Official Full Name: UDP-N-acetylglucosamine/UDP-N-acetylgalactosaminetransporter nstp-4
Primary source: WormBase:WBGene00015404
Locus tag: CELE_C03H5.2
See related: AllianceGenome:WB:WBGene00015404
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables UDP-N-acetylgalactosamine transmembrane transporter activity and UDP-N-acetylglucosamine transmembrane transporter activity. Involved in UDP-N-acetylgalactosamine transmembrane transport and UDP-N-acetylglucosamine transmembrane transport. Located in Golgi membrane. Is expressed in several structures, including hypodermis; intestine; pharynx; reproductive system; and tail. Orthologous to human SLC35A3 (solute carrier family 35 member A3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nstp-4 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (388833..392732)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vesicles containing a deletion mutant of the C03H5.2 protein transport UDP-N-acetylglucosamine at rates comparable with that of wild-type transporter
Title: Independent and simultaneous translocation of two substrates by a nucleotide sugar transporter.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C03H5.2 (e-PCR)
- UniSTS:319985

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables UDP-N-acetylgalactosamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-N-acetylglucosamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-galactose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyrimidine nucleotide-sugar transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylgalactosamine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-N-acetylglucosamine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-galactose transmembrane import into Golgi lumen	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleotide-sugar transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-N-acetylglucosamine/UDP-N-acetylgalactosaminetransporter nstp-4

NP_493723.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

388833..392732

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061322.9 → NP_493723.3 UDP-N-acetylglucosamine/UDP-N-acetylgalactosaminetransporter nstp-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493723.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O16658

Conserved Domains (2) summary

pfam04142
Location:7 → 326

Nuc_sug_transp; Nucleotide-sugar transporter

cl23754
Location:95 → 325

EamA; EamA-like transporter family