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prp-21 uncharacterized protein [ Caenorhabditis elegans ]

Gene ID: 173440, updated on 2-Nov-2024

Summary

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Official Symbol
prp-21
Official Full Name
uncharacterized protein
Primary source
WormBase:WBGene00004188
Locus tag
CELE_W07E6.4
See related
AllianceGenome:WB:WBGene00004188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of U2 snRNP; U2-type prespliceosome; and catalytic step 2 spliceosome. Orthologous to human SF3A1 (splicing factor 3a subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See prp-21 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (484866..490403)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene 26S rRNA (cytosine-C(5))-methyltransferase nsun-1 Neighboring gene G_PROTEIN_RECEP_F2_4 domain-containing protein Neighboring gene NLE domain-containing protein;WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene Sphingomyelin synthase-related 2 Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins. Spikes DA, et al. Nucleic Acids Res, 1994 Oct 25. PMID 7971282, Free PMC Article
  2. Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans. Ham S, et al. Genome Res, 2022 Nov-Dec. PMID 36351769, Free PMC Article
  3. Functional genomic analysis of RNA interference in C. elegans. Kim JK, et al. Science, 2005 May 20. PMID 15790806
  4. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Crawford ED, et al. Cell Death Differ, 2012 Dec. PMID 22918439, Free PMC Article
  5. ABCE1 is a highly conserved RNA silencing suppressor. Kärblane K, et al. PLoS One, 2015. PMID 25659154, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
NP_493746.1
  • Product from WormBase gene class prp;
    Confirmed by transcript evidence; yeast PRP (splicing factor) related

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    484866..490403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061345.10 → NP_493746.1  uncharacterized protein CELE_W07E6.4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493746.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECL3
    Conserved Domains (4) summary
    cd01800
    Location:580 → 655
    SF3a120_C; Ubiquitin-like domain of Mammalian splicing factor SF3a_120
    smart00648
    Location:35 → 88
    SWAP; Suppressor-of-White-APricot splicing regulator
    smart00213
    Location:577 → 648
    UBQ; Ubiquitin homologues
    pfam12230
    Location:197 → 409
    PRP21_like_P; Pre-mRNA splicing factor PRP21 like protein
Nucleotide Protein
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