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mlt-10 Molting protein mlt-10 [ Caenorhabditis elegans ]

Gene ID: 173445, updated on 2-Nov-2024

Summary

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Official Symbol
mlt-10
Official Full Name
Molting protein mlt-10
Primary source
WormBase:WBGene00015646
Locus tag
CELE_C09E8.3
See related
AllianceGenome:WB:WBGene00015646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and epidermis development. Located in extracellular space. Is expressed in hypodermal cell and pharyngeal epithelial cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mlt-10 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (546705..552032)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neighboring gene F-box associated domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene LIPaSe related;Triacylglycerol lipase Neighboring gene Sodium-and chloride-dependent glycine transporter 2 Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Experimental considerations for study of C. elegans lysosomal proteins. Clancy JC, et al. G3 (Bethesda), 2023 Apr 11. PMID 36748711, Free PMC Article
  2. GRD-1/PTR-11, the C. elegans hedgehog/patched-like morphogen-receptor pair, modulates developmental rate. Emans SW, et al. Development, 2023 Dec 15. PMID 37982457,
  3. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Hayes GD, et al. Development, 2006 Dec. PMID 17065234
  4. MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Meli VS, et al. Mol Biol Cell, 2010 May 15. PMID 20335506, Free PMC Article
  5. Epidermal PAR-6 and PKC-3 are essential for larval development of C. elegans and organize non-centrosomal microtubules. Castiglioni VG, et al. Elife, 2020 Dec 10. PMID 33300872, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mlt-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.
    Title: MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epidermis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Molting protein mlt-10
NP_493755.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    546705..552032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061354.5 → NP_493755.1  Molting protein mlt-10 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493755.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76555
    Conserved Domains (1) summary
    pfam04870
    Location:189 → 502
    Moulting_cycle; Moulting cycle
Nucleotide Protein
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