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thoc-1 Death domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173460, updated on 2-Nov-2024

Summary

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Official Symbol
thoc-1
Official Full Name
Death domain-containing protein
Primary source
WormBase:WBGene00020172
Locus tag
CELE_T02H6.2
See related
AllianceGenome:WB:WBGene00020172
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mRNA export from nucleus. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human THOC1 (THO complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See thoc-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
15
Sequence:
Chromosome: II; NC_003280.10 (702107..708608)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BgtE- Neighboring gene Cytochrome b-c1 complex subunit 7 Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene FIP-RBD domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival. Maeder CI, et al. Cell, 2018 Sep 6. PMID 30146163, Free PMC Article
  2. The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. Castellano-Pozo M, et al. PLoS One, 2012. PMID 23285047, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of THO complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Death domain-containing protein
NP_493796.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    702107..708608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061395.3 → NP_493796.2  Death domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493796.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N5E3
    Conserved Domains (1) summary
    pfam11957
    Location:63 → 492
    efThoc1; THO complex subunit 1 transcription elongation factor
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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