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sut-1 SUppressor of Tau pathology [ Caenorhabditis elegans ]

Gene ID: 173496, updated on 2-Nov-2024

Summary

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Official Symbol
sut-1
Official Full Name
SUppressor of Tau pathology
Primary source
WormBase:WBGene00020475
Locus tag
CELE_T13B5.8
See related
AllianceGenome:WB:WBGene00020475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Located in cytoplasm and nucleus. Is expressed widely. Used to study tauopathy. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sut-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (1121013..1123265, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene LIPaSe related Neighboring gene LIPaSe related Neighboring gene Reverse transcriptase domain-containing protein Neighboring gene TAF (TBP-associated transcription factor) family;TAF6 C-terminal HEAT repeat domain-containing protein;Transcription initiation factor TFIID subunit 6 Neighboring gene Elongator complex protein 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SUT-1 enables tau-induced neurotoxicity in C. elegans. Kraemer BC, et al. Hum Mol Genet, 2007 Aug 15. PMID 17576746
  2. A novel family of C. elegans snRNPs contains proteins associated with trans-splicing. MacMorris M, et al. RNA, 2007 Apr. PMID 17283210, Free PMC Article
  3. An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assembly. Philippe L, et al. Nucleic Acids Res, 2017 Aug 21. PMID 28582530, Free PMC Article
  4. A novel, essential trans-splicing protein connects the nematode SL1 snRNP to the CBC-ARS2 complex. Fasimoye RY, et al. Nucleic Acids Res, 2022 Jul 22. PMID 35736244, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SUppressor of Tau pathology
NP_001122639.1
  • Product from WormBase gene class sut;
    Confirmed by transcript evidence
NP_493917.2
  • Product from WormBase gene class sut;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    1121013..1123265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129167.3 → NP_001122639.1  SUppressor of Tau pathology [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122639.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9D649

  2. NM_061516.6 → NP_493917.2  SUppressor of Tau pathology [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493917.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYJ0
Nucleotide Protein
Heading Accession and Version

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