pod-2 acetyl-CoA carboxylase;biotin carboxylase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pod-2
Official Full Name: acetyl-CoA carboxylase;biotin carboxylase
Primary source: WormBase:WBGene00004076
Locus tag: CELE_W09B6.1
See related: AllianceGenome:WB:WBGene00004076
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable acetyl-CoA carboxylase activity. Involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; nematode larval development; and polarity specification of anterior/posterior axis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrion. Is expressed in CAN; excretory duct; hypodermis; intestine; and reproductive system. Used to study muscular disease. Orthologous to several human genes including ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pod-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 11

Sequence:: Chromosome: II; NC_003280.10 (1136785..1152701)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W09B6.1 (e-PCR)
- UniSTS:311158

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA carboxylase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malonyl-CoA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarity specification of anterior/posterior axis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: acetyl-CoA carboxylase;biotin carboxylase

NP_001022401.1

Confirmed by transcript evidence

NP_001254027.1

Confirmed by transcript evidence

NP_001380055.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

1136785..1152701

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392999.1 → NP_001380055.1 acetyl-CoA carboxylase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q9GZI3

Conserved Domains (5) summary

cd06850
Location:688 → 754

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

COG0439
Location:48 → 554

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:606 → 754

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam01039
Location:1428 → 1965

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:811 → 926

ACC_central; Acetyl-CoA carboxylase, central region
NM_001267098.3 → NP_001254027.1 acetyl-CoA carboxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254027.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L0M0

Conserved Domains (8) summary

cd06850
Location:799 → 865

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

COG0439
Location:159 → 665

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:717 → 865

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00289
Location:159 → 279

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam01039
Location:1539 → 2076

Carboxyl_trans; Carboxyl transferase domain

pfam02785
Location:552 → 659

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam08326
Location:922 → 1037

ACC_central; Acetyl-CoA carboxylase, central region

cl17255
Location:284 → 518

ATP-grasp_4; ATP-grasp domain
NM_001027230.7 → NP_001022401.1 biotin carboxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022401.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KQ29

Conserved Domains (6) summary

COG0439
Location:48 → 554

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:606 → 731

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00289
Location:48 → 168

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02785
Location:441 → 548

Biotin_carb_C; Biotin carboxylase C-terminal domain

cl11404
Location:688 → 733

Biotinyl_lipoyl_domains; Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, ...

cl17255
Location:173 → 407

ATP-grasp_4; ATP-grasp domain