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F53A10.2 Rap-GAP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173502, updated on 2-Nov-2024

Summary

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Official Symbol
F53A10.2
Official Full Name
Rap-GAP domain-containing protein
Primary source
WormBase:WBGene00018734
Locus tag
CELE_F53A10.2
See related
AllianceGenome:WB:WBGene00018734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be active in cytoplasm. Is expressed in intestine; neurons; and seam cell. Orthologous to human RAP1GAP (RAP1 GTPase activating protein) and RAP1GAP2 (RAP1 GTPase activating protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F53A10.2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
13
Sequence:
Chromosome: II; NC_003280.10 (1197374..1230782)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Zinc metalloproteinase nas-27 Neighboring gene PAS domain-containing protein;Period protein homolog lin-42 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteins interacting with Caenorhabditis elegans Galpha subunits. Cuppen E, et al. Comp Funct Genomics, 2003. PMID 18629017, Free PMC Article
  2. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rap-GAP domain-containing protein
NP_001022190.1
  • Partially confirmed by transcript evidence
NP_001309564.1
  • Confirmed by transcript evidence
NP_001309565.1
  • Confirmed by transcript evidence
NP_001309566.1
  • Confirmed by transcript evidence
NP_001379965.1
  • Confirmed by transcript evidence
NP_001379966.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    1197374..1230782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393000.1 → NP_001379965.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86RS9, Q965M4
    Conserved Domains (2) summary
    smart00390
    Location:79 → 101
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:313 → 492
    Rap_GAP; Rap/ran-GAP

  2. NM_001393001.1 → NP_001379966.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IA84
    Conserved Domains (1) summary
    pfam02145
    Location:1 → 126
    Rap_GAP; Rap/ran-GAP

  3. NM_001322701.3 → NP_001309564.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBF2, Q86RS9
    Conserved Domains (2) summary
    smart00390
    Location:18 → 40
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:252 → 431
    Rap_GAP; Rap/ran-GAP

  4. NM_001027019.3 → NP_001022190.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022190.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L055
    Conserved Domains (1) summary
    pfam02145
    Location:382 → 561
    Rap_GAP; Rap/ran-GAP

  5. NM_001322702.3 → NP_001309565.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBM3, Q86RS9
    Conserved Domains (1) summary
    pfam02145
    Location:179 → 358
    Rap_GAP; Rap/ran-GAP

  6. NM_001322703.3 → NP_001309566.1  Rap-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MCP2
    Conserved Domains (1) summary
    pfam02145
    Location:157 → 336
    Rap_GAP; Rap/ran-GAP
Nucleotide Protein
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