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fcho-1 FCH domain only protein 2 [ Caenorhabditis elegans ]

Gene ID: 173511, updated on 2-Nov-2024

Summary

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Official Symbol
fcho-1
Official Full Name
FCH domain only protein 2
Primary source
WormBase:WBGene00018974
Locus tag
CELE_F56D12.6
See related
AllianceGenome:WB:WBGene00018974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in clathrin-dependent endocytosis. Located in plasma membrane. Is expressed in amphid neurons; hypodermis; intestine; pharyngeal cell; and rectal gland cell. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including FCHO2 (FCH and mu domain containing endocytic adaptor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fcho-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
14
Sequence:
Chromosome: II; NC_003280.10 (1310515..1320439)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ER membrane protein complex subunit 2 Neighboring gene ncRNA Neighboring gene Aldehyde dehydrogenase domain-containing protein;L-glutamate gamma-semialdehyde dehydrogenase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Hyaluronan/mRNA-binding protein domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Eps15 membrane-binding and -bending activity acts redundantly with Fcho1 during clathrin-mediated endocytosis. Wang L, et al. Mol Biol Cell, 2016 Sep 1. PMID 27385343, Free PMC Article
  2. The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex. Hollopeter G, et al. Elife, 2014 Oct 10. PMID 25303366, Free PMC Article
  3. Regulation of ubiquitin-dependent cargo sorting by multiple endocytic adaptors at the plasma membrane. Mayers JR, et al. Proc Natl Acad Sci U S A, 2013 Jul 16. PMID 23818590, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The membrane-associated proteins FCHO1 and SGIP1 are allosteric activators of the AP2 clathrin adaptor complex.
    Title: The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
FCH domain only protein 2
NP_493947.1
  • Confirmed by transcript evidence
NP_493948.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    1310515..1320439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061546.4 → NP_493947.1  FCH domain only protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493947.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TXS0
    Conserved Domains (2) summary
    cd07648
    Location:14 → 274
    F-BAR_FCHO; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only proteins
    cl10970
    Location:689 → 963
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

  2. NM_061547.5 → NP_493948.1  FCH domain only protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493948.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYR2
    Conserved Domains (2) summary
    cl10970
    Location:672 → 946
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl12013
    Location:5 → 257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein
Heading Accession and Version

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