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vig-1 Hyaluronan/mRNA-binding protein domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173512, updated on 2-Nov-2024

Summary

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Official Symbol
vig-1
Official Full Name
Hyaluronan/mRNA-binding protein domain-containing protein
Primary source
WormBase:WBGene00006924
Locus tag
CELE_F56D12.5
See related
AllianceGenome:WB:WBGene00006924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Part of RISC complex. Is expressed in several structures, including excretory cell; hypodermis; intestine; nervous system; and reproductive system. Orthologous to human SERBP1 (SERPINE1 mRNA binding protein 1) and HABP4 (hyaluronan binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vig-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (1321037..1323073)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene FCH domain only protein 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene JNK-interacting protein 1;PID domain-containing protein Neighboring gene tRNA Neighboring gene tRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of C. elegans VIG-1 expression. Shin KH, et al. Mol Cells, 2008 Dec 31. PMID 18806471
  2. VIG-1 is required for maintenance of genome stability in Caenorhabditis elegans. Vasamsetti BMK, et al. Anim Cells Syst (Seoul), 2018. PMID 30460098, Free PMC Article
  3. The C. elegans VIG-1 and FRM-1 modulate carbachol-stimulated ERK1/2 activation in chinese hamster ovary cells expressing the muscarinic acetylcholine receptor GAR-3. Shin Y, et al. Neurochem Res, 2014 Apr. PMID 24604007
  4. TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells. Wang C, et al. Nucleic Acids Res, 2017 Feb 17. PMID 28180320, Free PMC Article
  5. A micrococcal nuclease homologue in RNAi effector complexes. Caudy AA, et al. Nature, 2003 Sep 25. PMID 14508492

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ERK1/2 activation is modulated by VIG-1 and FRM-1.
    Title: The C. elegans VIG-1 and FRM-1 modulate carbachol-stimulated ERK1/2 activation in chinese hamster ovary cells expressing the muscarinic acetylcholine receptor GAR-3.
  2. results indicate that the 406-bp upstream region (-596 to -191) contains essential regulatory sequences required for VIG-1 expression.
    Title: Analysis of C. elegans VIG-1 expression.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RISC complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Hyaluronan/mRNA-binding protein domain-containing protein
NP_001367502.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    1321037..1323073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381327.3 → NP_001367502.1  Hyaluronan/mRNA-binding protein domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYR1
    Conserved Domains (1) summary
    pfam04774
    Location:179 → 276
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
Nucleotide Protein
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