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cogc-4 Conserved oligomeric Golgi complex subunit 4 [ Caenorhabditis elegans ]

Gene ID: 173518, updated on 2-Nov-2024

Summary

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Official Symbol
cogc-4
Official Full Name
Conserved oligomeric Golgi complex subunit 4
Primary source
WormBase:WBGene00021784
Locus tag
CELE_Y51H7C.6
See related
AllianceGenome:WB:WBGene00021784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in gonad morphogenesis and regulation of cell migration. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in Saul-Wilson syndrome and congenital disorder of glycosylation type IIj. Orthologous to human COG4 (component of oligomeric golgi complex 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cogc-4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (1403441..1409118)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Nuclear nucleic acid-binding protein C1D Neighboring gene Immediate early response 3-interacting protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene L-serine deaminase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saul-Wilson Syndrome Missense Allele Does Not Show Obvious Golgi Defects in a C. elegans Model. Zafra I, et al. MicroPubl Biol, 2021 Mar 4. PMID 33688625, Free PMC Article
  2. The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans. Kubota Y, et al. Development, 2006 Jan. PMID 16354716
  3. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
  4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Conserved oligomeric Golgi complex subunit 4
NP_001033341.1
  • Confirmed by transcript evidence
NP_493966.1
  • Confirmed by transcript evidence
NP_493967.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    1403441..1409118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061565.7 → NP_493966.1  Conserved oligomeric Golgi complex subunit 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493966.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3V5K1, Q95XY9, Q95XZ0
    Conserved Domains (2) summary
    smart00762
    Location:198 → 527
    Cog4; COG4 transport protein
    pfam04437
    Location:562 → 789
    RINT1_TIP1; RINT-1 / TIP-1 family

  2. NM_001038252.4 → NP_001033341.1  Conserved oligomeric Golgi complex subunit 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001033341.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95XZ0
    Conserved Domains (1) summary
    cl07072
    Location:198 → 257
    COG4; COG4 transport protein

  3. NM_061566.7 → NP_493967.1  Conserved oligomeric Golgi complex subunit 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493967.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95XZ0
    Conserved Domains (1) summary
    smart00762
    Location:198 → 471
    Cog4; COG4 transport protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95XZ0.1

Gene LinkOut

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