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vab-19 ANK_REP_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173599, updated on 2-Nov-2024

Summary

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Official Symbol
vab-19
Official Full Name
ANK_REP_REGION domain-containing protein
Primary source
WormBase:WBGene00006882
Locus tag
CELE_T22D2.1
See related
AllianceGenome:WB:WBGene00006882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including actin cytoskeleton organization; cell-cell junction maintenance; and embryo development. Located in cell-cell junction; hemidesmosome; and intermediate filament. Is expressed in hypodermis; marginal cell; uterus; and vulD. Used to study cancer. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16; palmoplantar keratoderma and woolly hair; and spastic quadriplegic cerebral palsy 2. Orthologous to several human genes including KANK2 (KN motif and ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vab-19 in Genome Data Viewer
Location:
chromosome: II
Exon count:
18
Sequence:
Chromosome: II; NC_003280.10 (2443279..2450947)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. Ding M, et al. PLoS One, 2008 Oct 3. PMID 18833327, Free PMC Article
  2. Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine-vulval attachment in Caenorhabditis elegans. Ihara S, et al. Nat Cell Biol, 2011 Jun. PMID 21572423, Free PMC Article
  3. C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Ding M, et al. Development, 2003 Dec. PMID 14534136
  4. Muscle and epidermal contributions of the structural protein β-spectrin promote hypergravity-induced motor neuron axon defects in C. elegans. Kalichamy SS, et al. Sci Rep, 2020 Dec 3. PMID 33273580, Free PMC Article
  5. Extracellular matrix regulates UNC-6 (netrin) axon guidance by controlling the direction of intracellular UNC-40 (DCC) outgrowth activity. Yang Y, et al. PLoS One, 2014. PMID 24824544, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell junction maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-substrate junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in hemidesmosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intermediate filament IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ANK_REP_REGION domain-containing protein
NP_494276.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2443279..2450947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061875.4 → NP_494276.2  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494276.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDN8
    Conserved Domains (4) summary
    PHA03247
    Location:165 → 444
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:858 → 1020
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:863 → 895
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:940 → 1018
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein
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