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sqv-2 Beta-1,3-galactosyltransferase sqv-2 [ Caenorhabditis elegans ]

Gene ID: 173635, updated on 2-Nov-2024

Summary

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Official Symbol
sqv-2
Official Full Name
Beta-1,3-galactosyltransferase sqv-2
Primary source
WormBase:WBGene00005020
Locus tag
CELE_Y110A2AL.14
See related
AllianceGenome:WB:WBGene00005020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables galactosylxylosylprotein 3-beta-galactosyltransferase activity. Involved in several processes, including egg-laying behavior; glycosaminoglycan biosynthetic process; and vulval development. Located in Golgi apparatus. Is expressed in intestine. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome spondylodysplastic type 2 and spondyloepimetaphyseal dysplasia with joint laxity type 1. Orthologous to human B3GALT6 (beta-1,3-galactosyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sqv-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (2889116..2894395, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol-glycan biosynthesis class W protein Neighboring gene Peptidyl-prolyl cis-trans isomerase Neighboring gene ncRNA Neighboring gene E2 ubiquitin-conjugating enzyme Neighboring gene E2 ubiquitin-conjugating enzyme;UBIQUITIN_CONJUGAT_2 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase. Hwang HY, et al. J Biol Chem, 2003 Apr 4. PMID 12584198
  2. sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination. Herman T, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927677, Free PMC Article
  3. Mutations that perturb vulval invagination in C. elegans. Herman T, et al. Cold Spring Harb Symp Quant Biol, 1997. PMID 9598369
  4. Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate. Sugahara K, et al. Curr Opin Struct Biol, 2003 Oct. PMID 14568617
  5. C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans. Franks DM, et al. Dev Biol, 2006 Aug 15. PMID 16828468

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables galactosylxylosylprotein 3-beta-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosylxylosylprotein 3-beta-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactosylxylosylprotein 3-beta-galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chondroitin sulfate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycosaminoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosaminoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Beta-1,3-galactosyltransferase sqv-2
NP_494394.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2889116..2894395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061993.9 → NP_494394.1  Beta-1,3-galactosyltransferase sqv-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494394.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N491
    Conserved Domains (1) summary
    cl21608
    Location:72 → 259
    Galactosyl_T; Galactosyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N491.1

Gene LinkOut

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