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apd-3 AP-3 complex subunit delta;AP-3 complex subunit delta domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173701, updated on 2-Nov-2024

Summary

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Official Symbol
apd-3
Official Full Name
AP-3 complex subunit delta;AP-3 complex subunit delta domain-containing protein
Primary source
WormBase:WBGene00000162
Locus tag
CELE_W09G10.4
See related
AllianceGenome:WB:WBGene00000162
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in synaptic vesicle membrane organization; synaptic vesicle transport; and vacuolar transport. Predicted to be located in Golgi apparatus and axon cytoplasm. Predicted to be part of AP-3 adaptor complex. Predicted to be active in endosome membrane; presynaptic endosome; and terminal bouton. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome. Orthologous to human AP3D1 (adaptor related protein complex 3 subunit delta 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See apd-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
15
Sequence:
Chromosome: II; NC_003280.10 (3532527..3546431, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene DUF4105 domain-containing protein Neighboring gene DyNactin Complex component

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans. Shim J, et al. Mol Cells, 2005 Jun 30. PMID 15995364
  2. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Kamikura DM, et al. Genes Dev, 2003 Nov 15. PMID 14630941, Free PMC Article
  3. Two Clathrin Adaptor Protein Complexes Instruct Axon-Dendrite Polarity. Li P, et al. Neuron, 2016 May 4. PMID 27151641, Free PMC Article
  4. Adaptins: the final recount. Boehm M, et al. Mol Biol Cell, 2001 Oct. PMID 11598180, Free PMC Article
  5. Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. Yang S, et al. Neuron, 2022 Mar 2. PMID 35065714, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anterograde synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle budding from endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-3 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-3 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
AP-3 complex subunit delta;AP-3 complex subunit delta domain-containing protein
NP_494570.1
  • Confirmed by transcript evidence
NP_494571.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    3532527..3546431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062169.7 → NP_494570.1  AP-3 complex subunit delta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494570.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16637
    Conserved Domains (4) summary
    pfam01602
    Location:32 → 581
    Adaptin_N; Adaptin N terminal region
    pfam06375
    Location:692 → 853
    BLVR; Bovine leukaemia virus receptor (BLVR)
    pfam12717
    Location:153 → 265
    Cnd1; non-SMC mitotic condensation complex subunit 1
    sd00044
    Location:223 → 247
    HEAT; HEAT repeat [structural motif]

  2. NM_062170.5 → NP_494571.1  AP-3 complex subunit delta domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494571.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95X88
    Conserved Domains (3) summary
    pfam01602
    Location:1 → 309
    Adaptin_N; Adaptin N terminal region
    pfam06375
    Location:420 → 581
    BLVR; Bovine leukaemia virus receptor (BLVR)
    sd00044
    Location:30 → 60
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
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