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sco-1 Thioredoxin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173763, updated on 2-Nov-2024

Summary

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Official Symbol
sco-1
Official Full Name
Thioredoxin domain-containing protein
Primary source
WormBase:WBGene00015297
Locus tag
CELE_C01F1.2
See related
AllianceGenome:WB:WBGene00015297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable copper chaperone activity and copper ion binding activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrial inner membrane. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease; hypertrophic cardiomyopathy; mitochondrial complex IV deficiency nuclear type 2; mitochondrial complex IV deficiency nuclear type 4; and myopia. Orthologous to several human genes including SCO1 (synthesis of cytochrome C oxidase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sco-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (4299653..4300845)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NAD(P)-bd_dom domain-containing protein;NAD(P)-binding domain-containing protein Neighboring gene Transcription initiation factor IIF subunit alpha Neighboring gene protein-disulfide reductase Neighboring gene UNC93-like protein MFSD11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Impaired p53/CEP-1 is associated with lifespan extension through an age-related imbalance in the energy metabolism of C. elegans. Yanase S, et al. Genes Cells, 2017 Dec. PMID 29114996
  2. Real-Time PCR Analysis of Metabolism-Related Genes in a Long-Lived Model of C. elegans. Yanase S. Methods Mol Biol, 2020. PMID 32219749
  3. Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. Maglioni S, et al. Nat Commun, 2022 May 12. PMID 35551180, Free PMC Article
  4. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Chen D, et al. Aging Cell, 2007 Aug. PMID 17521386, Free PMC Article
  5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables copper chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular copper ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in respiratory chain complex IV assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Thioredoxin domain-containing protein
NP_494755.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4299653..4300845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062354.7 → NP_494755.1  Thioredoxin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494755.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17557
    Conserved Domains (1) summary
    cd02968
    Location:137 → 281
    SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...
Nucleotide Protein
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