hlh-1 Myoblast determination protein 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hlh-1
Official Full Name: Myoblast determination protein 1 homolog
Primary source: WormBase:WBGene00001948
Locus tag: CELE_B0304.1
See related: AllianceGenome:WB:WBGene00001948
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in positive regulation of mesodermal cell fate specification; positive regulation of transcription by RNA polymerase II; and striated muscle cell differentiation. Acts upstream of or within positive regulation of muscle cell differentiation. Located in nucleus. Is expressed in several structures, including C lineage cell; Capa; D lineage cell; I4 neuron; and body wall muscle cell. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in congenital myopathy 17 and congenital structural myopathy. Orthologous to several human genes including MYOD1 (myogenic differentiation 1); MYF5 (myogenic factor 5); and MYF6 (myogenic factor 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hlh-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (4519063..4522526)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Imaging of native transcription and transcriptional dynamics in vivo using a tagged Argonaute protein.
Title: Imaging of native transcription and transcriptional dynamics in vivo using a tagged Argonaute protein.
Multilevel regulation of muscle-specific transcription factor hlh-1 during Caenorhabditis elegans embryogenesis.
Title: Multilevel regulation of muscle-specific transcription factor hlh-1 during Caenorhabditis elegans embryogenesis.
We found that HLH-1-dependent myogenic conversion specifically induced the expression of putative HLH-1-regulated chaperones in differentiating muscle cells. Moreover, disrupting the putative HLH-1-binding sites on ubiquitously expressed daf-21(Hsp90) and muscle-enriched hsp-12.2(sHsp) promoters abolished their myogenic-dependent expressio
Title: A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans.
hlh-1 is indeed a direct target of PAL-1 in the posterior embryonic C. elegans muscle lineages, defining a novel in vivo binding site for this crucial developmental regulator
Title: Caudal-like PAL-1 directly activates the bodywall muscle module regulator hlh-1 in C. elegans to initiate the embryonic muscle gene regulatory network.
findings demonstrate that UNC-120/SRF and HND-1/HAND act in concert with HLH-1 to regulate myogenesis
Title: Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development.
CeMyoD (HLH-1) is a myogenic regulatory factor that can convert almost all cells to a muscle-like fate, regardless of their lineage of origin.
Title: The myogenic potency of HLH-1 reveals wide-spread developmental plasticity in early C. elegans embryos.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0304.1 (e-PCR)
- UniSTS:313388

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of myoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in striated muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Myoblast determination protein 1 homolog

NP_001021892.1

Confirmed by transcript evidence

NP_001021893.1

Confirmed by transcript evidence

NP_001367340.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

4519063..4522526

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026722.5 → NP_001021893.1 Myoblast determination protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021893.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P22980

Conserved Domains (1) summary

cd00083
Location:153 → 211

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001381393.1 → NP_001367340.1 Myoblast determination protein 1 homolog [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd19699
Location:151 → 206

bHLH_TS_dMYOD_like; basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster myogenic-determination protein (dMYOD) and similar proteins
NM_001026721.3 → NP_001021892.1 Myoblast determination protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021892.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P22980

Conserved Domains (1) summary

cd00083
Location:153 → 211

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...