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lgc-27 Neurotransmitter-gated ion-channel ligand-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173802, updated on 2-Nov-2024

Summary

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Official Symbol
lgc-27
Official Full Name
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein
Primary source
WormBase:WBGene00022283
Locus tag
CELE_Y74E4A.1
See related
AllianceGenome:WB:WBGene00022283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in AIYL and AIYR. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lgc-27 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (4649085..4653283)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Protein quiver Neighboring gene Rootletin Neighboring gene ncRNA Neighboring gene Alpha-(1,3)-fucosyltransferase fut-6 Neighboring gene DUF38 domain-containing protein Neighboring gene Tyrosine-protein phosphatase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein
NP_740977.1
  • Confirmed by transcript evidence
NP_740978.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4649085..4653283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170980.4 → NP_740977.1  Neurotransmitter-gated ion-channel ligand-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740977.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZY7
    Conserved Domains (2) summary
    cd03558
    Location:181 → 195
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:79 → 248
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

  2. NM_171848.7 → NP_740978.1  Neurotransmitter-gated ion-channel ligand-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740978.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8TA50
    Conserved Domains (2) summary
    cd03558
    Location:181 → 195
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:79 → 248
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
Nucleotide Protein
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