unc-85 putative histone chaperone asf-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-85
Official Full Name: putative histone chaperone asf-1
Primary source: WormBase:WBGene00006817
Locus tag: CELE_F10G7.3
See related: AllianceGenome:WB:WBGene00006817
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable histone binding activity. Involved in egg-laying behavior and post-embryonic development. Located in nucleus. Is expressed in several structures, including germ line. Orthologous to human ASF1A (anti-silencing function 1A histone chaperone). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-85 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (4702069..4703219)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of the histone chaperone UNC-85/ASF1 inhibits the epigenome-mediated longevity and modulates the activity of one-carbon metabolism.
Title: Loss of the histone chaperone UNC-85/ASF1 inhibits the epigenome-mediated longevity and modulates the activity of one-carbon metabolism.
study cloned the unc-85 gene, and found that it encodes 1 of 2 C. elegans homologs of the yeast Asf1 histone chaperone; it is expressed in replicating cells throughout development, and the protein is localized in nuclei
Title: UNC-85, a C. elegans homolog of the histone chaperone Asf1, functions in post-embryonic neuroblast replication.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F10G7.3 (e-PCR)
- UniSTS:309670

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA replication-dependent chromatin assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in nucleosome disassembly	IEA Inferred from Electronic Annotation more info
involved_in post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative histone chaperone asf-1

NP_494837.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

4702069..4703219

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062436.5 → NP_494837.2 putative histone chaperone asf-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494837.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19326

Conserved Domains (1) summary

pfam04729
Location:3 → 154

ASF1_hist_chap; ASF1 like histone chaperone