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acs-11 fatty Acid CoA Synthetase family [ Caenorhabditis elegans ]

Gene ID: 173820, updated on 2-Nov-2024

Summary

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Official Symbol
acs-11
Official Full Name
fatty Acid CoA Synthetase family
Primary source
WormBase:WBGene00018269
Locus tag
CELE_F41C3.3
See related
AllianceGenome:WB:WBGene00018269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable medium-chain fatty acid-CoA ligase activity. Involved in IRE1-mediated unfolded protein response. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in combined malonic and methylmalonic acidemia. Orthologous to human ACSF3 (acyl-CoA synthetase family member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acs-11 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (4742137..4745280)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serine carboxypeptidase ctsa-1.1 Neighboring gene putative Golgi transport protein 1 Neighboring gene MFS domain-containing protein Neighboring gene Exocyst complex component Sec8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cadmium accelerates bacterial oleic acid production to promote fat accumulation in Caenorhabditis elegans. Ma X, et al. J Hazard Mater, 2022 Jan 5. PMID 34325294
  2. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Taubert S, et al. Genes Dev, 2006 May 1. PMID 16651656, Free PMC Article
  3. Lysinibacillus sphaericus mediates stress responses and attenuates arsenic toxicity in Caenorhabditis elegans. Mangu JCK, et al. Sci Total Environ, 2022 Aug 20. PMID 35460794
  4. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478
  5. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables medium-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fatty Acid CoA Synthetase family
NP_494848.3
  • Product from WormBase gene class acs;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4742137..4745280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062447.10 → NP_494848.3  fatty Acid CoA Synthetase family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494848.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20264
    Conserved Domains (2) summary
    PRK07514
    Location:34 → 505
    PRK07514; malonyl-CoA synthase; Validated
    cd05941
    Location:37 → 493
    MCS; Malonyl-CoA synthetase (MCS)
Nucleotide Protein
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