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gst-7 putative glutathione S-transferase 7 [ Caenorhabditis elegans ]

Gene ID: 173842, updated on 2-Nov-2024

Summary

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Official Symbol
gst-7
Official Full Name
putative glutathione S-transferase 7
Primary source
WormBase:WBGene00001755
Locus tag
CELE_F11G11.2
See related
AllianceGenome:WB:WBGene00001755
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutathione transferase activity. Involved in innate immune response. Is expressed in germ line; head; hypodermis; and intestine. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gst-7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003280.10 (4882062..4883358)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene arginine kinase Neighboring gene putative glutathione S-transferase 6 Neighboring gene putative glutathione S-transferase 8 Neighboring gene Serpentine Receptor, class E (Epsilon)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Binding of hematin by a new class of glutathione transferase from the blood-feeding parasitic nematode Haemonchus contortus. van Rossum AJ, et al. Infect Immun, 2004 May. PMID 15102788, Free PMC Article
  2. Screening and analysis of Hc-ubq and Hc-gst related to desiccation survival of infective Haemonchus contortus larvae. Yang Y, et al. Vet Parasitol, 2015 Jun 15. PMID 25913452
  3. Heme transport and detoxification in nematodes: subproteomics evidence of differential role of glutathione transferases. Perally S, et al. J Proteome Res, 2008 Oct. PMID 18720983
  4. Structured Docosahexaenoic Acid (DHA) Enhances Motility and Promotes the Antioxidant Capacity of Aged C. elegans. Mora I, et al. Cells, 2023 Jul 26. PMID 37566010, Free PMC Article
  5. Arginine methylation of SKN-1 promotes oxidative stress resistance in Caenorhabditis elegans. Li H, et al. Redox Biol, 2019 Feb. PMID 30682707, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response HEP PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
putative glutathione S-transferase 7
NP_494883.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    4882062..4883358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062482.8 → NP_494883.1  putative glutathione S-transferase 7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494883.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91253
    Conserved Domains (3) summary
    PTZ00057
    Location:8 → 201
    PTZ00057; glutathione s-transferase; Provisional
    cd03192
    Location:83 → 188
    GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
    cd03039
    Location:4 → 73
    GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91253.1

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