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ampd-1 AMP deaminase [ Caenorhabditis elegans ]

Gene ID: 173891, updated on 2-Nov-2024

Summary

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Official Symbol
ampd-1
Official Full Name
AMP deaminase
Primary source
WormBase:WBGene00016415
Locus tag
CELE_C34F11.3
See related
AllianceGenome:WB:WBGene00016415
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable AMP deaminase activity. Predicted to be involved in AMP metabolic process and IMP biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including anal depressor muscle; hypodermis; nervous system; pharyngeal-intestinal valve; and reproductive system. Human ortholog(s) of this gene implicated in congestive heart failure; coronary artery disease; hereditary spastic paraplegia 63; and pontocerebellar hypoplasia type 9. Orthologous to several human genes including AMPD2 (adenosine monophosphate deaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ampd-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
21
Sequence:
Chromosome: II; NC_003280.10 (5203322..5209801)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein kinase Neighboring gene Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142 Neighboring gene Glycine-rich protein Neighboring gene DUF4440 domain-containing protein Neighboring gene RING-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables AMP deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables AMP deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in AMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IMP salvage IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
AMP deaminase
NP_001040752.2
  • Confirmed by transcript evidence
NP_001343751.1
  • Partially confirmed by transcript evidence
NP_494973.3
  • Confirmed by transcript evidence
NP_494974.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5203322..5209801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062573.6 → NP_494974.3  AMP deaminase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494974.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZ18
    Conserved Domains (2) summary
    PLN03055
    Location:159 → 777
    PLN03055; AMP deaminase; Provisional
    TIGR01429
    Location:162 → 775
    AMP_deaminase; AMP deaminase

  2. NM_001047287.5 → NP_001040752.2  AMP deaminase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040752.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZ19
    Conserved Domains (2) summary
    PLN03055
    Location:222 → 840
    PLN03055; AMP deaminase; Provisional
    TIGR01429
    Location:225 → 838
    AMP_deaminase; AMP deaminase

  3. NM_062572.7 → NP_494973.3  AMP deaminase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494973.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    D7SFL2
    Conserved Domains (2) summary
    PLN03055
    Location:243 → 815
    PLN03055; AMP deaminase; Provisional
    TIGR01429
    Location:186 → 813
    AMP_deaminase; AMP deaminase

  4. NM_001356832.3 → NP_001343751.1  AMP deaminase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C377
    Conserved Domains (1) summary
    TIGR01429
    Location:312 → 939
    AMP_deaminase; AMP deaminase
Nucleotide Protein
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