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rsp-4 putative splicing factor, arginine/serine-rich 4 [ Caenorhabditis elegans ]

Gene ID: 173915, updated on 2-Nov-2024

Summary

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Official Symbol
rsp-4
Official Full Name
putative splicing factor, arginine/serine-rich 4
Primary source
WormBase:WBGene00004701
Locus tag
CELE_EEED8.7
See related
AllianceGenome:WB:WBGene00004701
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed widely. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congestive heart failure; hepatocellular carcinoma; and myelodysplastic syndrome. Orthologous to several human genes including SRSF2 (serine and arginine rich splicing factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rsp-4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (5387411..5388836, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein kinase C-like 3 Neighboring gene Cytosolic carboxypeptidase 6 Neighboring gene Putative nudix hydrolase 6 Neighboring gene BRCA1-associated protein homolog 2 Neighboring gene Serine/threonine-protein kinase pink-1, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative splicing and the steady-state ratios of mRNA isoforms generated by it are under strong stabilizing selection in Caenorhabditis elegans. Barberan-Soler S, et al. Mol Biol Evol, 2008 Nov. PMID 18718918, Free PMC Article
  2. Unique and redundant functions of SR proteins, a conserved family of splicing factors, in Caenorhabditis elegans development. Kawano T, et al. Mech Dev, 2000 Jul. PMID 10906451
  3. SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. Pak SC, et al. J Biol Chem, 2004 Apr 9. PMID 14739286
  4. U12 type introns were lost at multiple occasions during evolution. Bartschat S, et al. BMC Genomics, 2010 Feb 11. PMID 20149226, Free PMC Article
  5. Caenorhabditis elegans SMG-2 selectively marks mRNAs containing premature translation termination codons. Johns L, et al. Mol Cell Biol, 2007 Aug. PMID 17562857, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative splicing factor, arginine/serine-rich 4
NP_001379856.1
  • Confirmed by transcript evidence
NP_495014.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5387411..5388836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393068.1 → NP_001379856.1  putative splicing factor, arginine/serine-rich 4 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09511, Q95QN7
    Conserved Domains (1) summary
    cd12311
    Location:21 → 93
    RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

  2. NM_062613.4 → NP_495014.1  putative splicing factor, arginine/serine-rich 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495014.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09511
    Conserved Domains (2) summary
    COG0724
    Location:19 → 96
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12311
    Location:21 → 93
    RRM_SRSF2_SRSF8; RNA recognition motif in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09511.1

Gene LinkOut

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