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acdh-2 Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein;Acyl-CoA_dh_N domain-containing protein;Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 173940, updated on 2-Nov-2024

Summary

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Official Symbol
acdh-2
Official Full Name
Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein;Acyl-CoA_dh_N domain-containing protein;Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Primary source
WormBase:WBGene00015894
Locus tag
CELE_C17C3.12
See related
AllianceGenome:WB:WBGene00015894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acyl-CoA dehydrogenase activity. Predicted to be active in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; and muscle cell. Orthologous to human ACADSB (acyl-CoA dehydrogenase short/branched chain). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acdh-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (5544778..5547492, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene INSulin related Neighboring gene F-box domain-containing protein Neighboring gene DUF38 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans. Hall RA, et al. Mol Biochem Parasitol, 2008 Oct. PMID 18640159
  2. PQM-1 controls hypoxic survival via regulation of lipid metabolism. Heimbucher T, et al. Nat Commun, 2020 Oct 2. PMID 33009389, Free PMC Article
  3. A metabolic regulatory network for the Caenorhabditis elegans intestine. Bhattacharya S, et al. iScience, 2022 Aug 19. PMID 35847555, Free PMC Article
  4. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Taubert S, et al. Genes Dev, 2006 May 1. PMID 16651656, Free PMC Article
  5. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein;Acyl-CoA_dh_N domain-containing protein;Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
NP_001343623.1
  • Confirmed by transcript evidence
NP_001360428.1
  • Confirmed by transcript evidence
NP_001379683.1
  • Confirmed by transcript evidence
NP_001380222.1
  • Confirmed by transcript evidence
NP_495066.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5544778..5547492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393073.1 → NP_001379683.1  Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BIB0
    Conserved Domains (1) summary
    cl09933
    Location:38 → 90
    ACAD; Acyl-CoA dehydrogenase

  2. NM_001393074.1 → NP_001380222.1  Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C369
    Conserved Domains (1) summary
    pfam02771
    Location:37 → 133
    Acyl-CoA_dh_N; Acyl-CoA dehydrogenase, N-terminal domain

  3. NM_001373716.3 → NP_001360428.1  Acyl-CoA_dh_N domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C2X1
    Conserved Domains (1) summary
    cl09933
    Location:38 → 261
    ACAD; Acyl-CoA dehydrogenase

  4. NM_001356838.3 → NP_001343623.1  Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYU0
    Conserved Domains (1) summary
    cl09933
    Location:38 → 379
    ACAD; Acyl-CoA dehydrogenase

  5. NM_062665.9 → NP_495066.2  Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495066.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYT9
    Conserved Domains (2) summary
    COG1960
    Location:36 → 308
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]
    cl09933
    Location:38 → 308
    ACAD; Acyl-CoA dehydrogenase
Nucleotide Protein
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