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ttc-4 Cns1/TTC4 wheel domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173946, updated on 2-Nov-2024

Summary

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Official Symbol
ttc-4
Official Full Name
Cns1/TTC4 wheel domain-containing protein
Primary source
WormBase:WBGene00015916
Locus tag
CELE_C17G10.2
See related
AllianceGenome:WB:WBGene00015916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Hsp70 protein binding activity and Hsp90 protein binding activity. Predicted to be involved in protein folding. Predicted to be active in nucleus. Is expressed in several structures, including body wall musculature; intestine; nervous system; pharynx; and vulval muscle. Orthologous to human TTC4 (tetratricopeptide repeat domain 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ttc-4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (5594714..5596456)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene LYSozyme Neighboring gene THAP-type domain-containing protein Neighboring gene Tyrosine-protein phosphatase cdc-14 Neighboring gene uS12 prolyl 3-hydroxylase Neighboring gene DUF4440 domain-containing protein Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hsp90 in non-mammalian metazoan model systems. Haslbeck V, et al. Biochim Biophys Acta, 2012 Mar. PMID 21983200
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Cns1/TTC4 wheel domain-containing protein
NP_495087.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5594714..5596456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062686.6 → NP_495087.1  Cns1/TTC4 wheel domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495087.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q09974
    Conserved Domains (2) summary
    sd00006
    Location:95 → 123
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:94 → 164
    TPR_11; TPR repeat
Nucleotide Protein
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