C17G10.1 uS12 prolyl 3-hydroxylase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: C17G10.1
Official Full Name: uS12 prolyl 3-hydroxylase
Primary source: WormBase:WBGene00015915
Locus tag: CELE_C17G10.1
See related: AllianceGenome:WB:WBGene00015915
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable peptidyl-proline dioxygenase activity. Predicted to be involved in regulation of translational termination. Predicted to be active in cytoplasm. Is expressed in hypodermis; intestine; and nervous system. Orthologous to human OGFOD1 (2-oxoglutarate and iron dependent oxygenase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See C17G10.1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (5596547..5598449)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C17G10.1 (e-PCR)
- UniSTS:308589

C17G10.2 (e-PCR)
- UniSTS:306562

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 2-oxoglutarate-dependent dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables peptidyl-proline dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-proline dioxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of translational termination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uS12 prolyl 3-hydroxylase

NP_495088.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5596547..5598449

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062687.9 → NP_495088.1 uS12 prolyl 3-hydroxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495088.1

Status: REVIEWED

UniProtKB/TrEMBL

Q09973

Conserved Domains (2) summary

smart00702
Location:54 → 239

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

pfam10637
Location:260 → 480

Ofd1_CTDD; Oxoglutarate and iron-dependent oxygenase degradation C-term