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eif-2D SUI1 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173964, updated on 2-Nov-2024

Summary

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Official Symbol
eif-2D
Official Full Name
SUI1 domain-containing protein
Primary source
WormBase:WBGene00016113
Locus tag
CELE_C25H3.4
See related
AllianceGenome:WB:WBGene00016113
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable translation initiation factor activity. Predicted to be involved in formation of translation preinitiation complex. Orthologous to human EIF2D (eukaryotic translation initiation factor 2D). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eif-2D in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (5691721..5693939)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial Neighboring gene Thioesterase domain-containing protein Neighboring gene Thioesterase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation. Sonobe Y, et al. Nat Commun, 2021 Oct 15. PMID 34654821, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of translation preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SUI1 domain-containing protein
NP_495114.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5691721..5693939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062713.7 → NP_495114.3  SUI1 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18186
    Conserved Domains (4) summary
    cd11608
    Location:457 → 540
    eIF2D_C; C-terminal domain of eIF2D and related proteins
    cd11610
    Location:6 → 77
    eIF2D_N; N-terminal domain of eIF2D and related proteins
    COG2016
    Location:15 → 181
    Tma20; Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ribosomal structure and biogenesis]
    cl00607
    Location:58 → 176
    PUA; PUA domain
Nucleotide Protein
Heading Accession and Version

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