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lect-2 Leukocyte cell-derived chemotaxin-2 homolog [ Caenorhabditis elegans ]

Gene ID: 173978, updated on 2-Nov-2024

Summary

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Official Symbol
lect-2
Official Full Name
Leukocyte cell-derived chemotaxin-2 homolog
Primary source
WormBase:WBGene00019407
Locus tag
CELE_K05F1.5
See related
AllianceGenome:WB:WBGene00019407
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Involved in innervation; regulation of dendrite extension; and regulation of dendrite morphogenesis. Located in several cellular components, including cell surface; perikaryon; and sensory dendrite. Is expressed in body wall musculature; coelomocyte; head neurons; and ventral cord neurons. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human LECT2 (leukocyte cell derived chemotaxin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lect-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (5790723..5794402)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene medium-chain acyl-CoA dehydrogenase Neighboring gene Major sperm protein 63

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Muscle- and Skin-Derived Cues Jointly Orchestrate Patterning of Somatosensory Dendrites. Díaz-Balzac CA, et al. Curr Biol, 2016 Sep 12. PMID 27451901, Free PMC Article
  2. A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans. Zou W, et al. Elife, 2016 Oct 5. PMID 27705746, Free PMC Article
  3. Convertase-dependent regulation of membrane-tethered and secreted ligands tunes dendrite adhesion. Ramirez-Suarez NJ, et al. Development, 2023 Sep 15. PMID 37721334, Free PMC Article
  4. A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching. Zou W, et al. Dev Cell, 2018 May 7. PMID 29738713, Free PMC Article
  5. The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning. Tang LTH, et al. PLoS Genet, 2021 Jul. PMID 34197450, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in innervation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dendrite extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in sensory dendrite IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Leukocyte cell-derived chemotaxin-2 homolog
NP_495141.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5790723..5794402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062740.8 → NP_495141.2  Leukocyte cell-derived chemotaxin-2 homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1B1LVF5, Q21241
    Conserved Domains (1) summary
    pfam01551
    Location:60 → 166
    Peptidase_M23; Peptidase family M23
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21241.3

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