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lec-5 Galectin [ Caenorhabditis elegans ]

Gene ID: 173992, updated on 2-Nov-2024

Summary

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Official Symbol
lec-5
Official Full Name
Galectin
Primary source
WormBase:WBGene00002268
Locus tag
CELE_ZK1248.16
See related
AllianceGenome:WB:WBGene00002268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable carbohydrate binding activity and galactoside binding activity. Located in membrane raft. Orthologous to human LGALS9 (galectin 9); LGALS9B (galectin 9B); and LGALS9C (galectin 9C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lec-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (5839639..5841103, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene WW domain-containing protein Neighboring gene Protein LZIC Neighboring gene ncRNA Neighboring gene Peptidase M13 C-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The galectin LEC-5 is a novel binding partner for RAB-11. Zhang N, et al. Biochem Biophys Res Commun, 2018 Oct 28. PMID 30274774
  2. Cholesterol-responsive metabolic proteins are required for larval development in Caenorhabditis elegans. Kawasaki I, et al. Mol Cells, 2013 Nov. PMID 24218109, Free PMC Article
  3. Caenorhabditis elegans galectins LEC-1-LEC-11: structural features and sugar-binding properties. Nemoto-Sasaki Y, et al. Biochim Biophys Acta, 2008 Oct. PMID 18675319
  4. A Caenorhabditis elegans glycolipid-binding galectin functions in host defense against bacterial infection. Ideo H, et al. J Biol Chem, 2009 Sep 25. PMID 19635802, Free PMC Article
  5. An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. Rao W, et al. J Proteomics, 2011 Feb 1. PMID 21070894

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of galectin LEC-5 as a direct physical interactor of RAB-11.
    Title: The galectin LEC-5 is a novel binding partner for RAB-11.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables galactoside binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane raft HDA PubMed 

General protein information

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Preferred Names
Galectin
NP_495163.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5839639..5841103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062762.11 → NP_495163.1  Galectin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495163.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFI4
    Conserved Domains (2) summary
    smart00276
    Location:42 → 170
    GLECT; Galectin
    cd00070
    Location:191 → 307
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
Nucleotide Protein
Heading Accession and Version

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