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vps-35 Vacuolar protein sorting-associated protein 35 [ Caenorhabditis elegans ]

Gene ID: 174000, updated on 2-Nov-2024

Summary

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Official Symbol
vps-35
Official Full Name
Vacuolar protein sorting-associated protein 35
Primary source
WormBase:WBGene00006933
Locus tag
CELE_F59G1.3
See related
AllianceGenome:WB:WBGene00006933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in positive regulation of protein localization to cell periphery; protein localization to postsynaptic membrane; and regulation of presynapse assembly. Located in cytosol; dendrite; and neuronal cell body. Is expressed in several structures, including body wall musculature; ciliated neurons; coelomocyte; intestine; and pharynx. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 17. Orthologous to human VPS35 (VPS35 retromer complex component). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vps-35 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (5907816..5911219)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene LisH domain-containing protein;VQ domain-containing protein Neighboring gene TetraSPanin family Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Ceramide glucosyltransferase 3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. VPS35 and EIF4G1 interactions and novel candidate genes for PD: from genes to pathways and back. Erro R. Mov Disord, 2015 Apr. PMID 25771811
  2. BMP signaling requires retromer-dependent recycling of the type I receptor. Gleason RJ, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550286, Free PMC Article
  3. SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes. Norris A, et al. Proc Natl Acad Sci U S A, 2017 Jan 17. PMID 28053230, Free PMC Article
  4. Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein. Harterink M, et al. Development, 2011 Jul. PMID 21653614, Free PMC Article
  5. The frataxin-encoding operon of Caenorhabditis elegans shows complex structure and regulation. Vázquez-Manrique RP, et al. Genomics, 2007 Mar. PMID 17174523

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The retromer protein vps-35 is required in Wnt-expressing cells.
    Title: Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein localization to cell periphery IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of presynapse assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in dendrite IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of retromer complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of retromer, cargo-selective complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vacuolar protein sorting-associated protein 35
NP_495180.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5907816..5911219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062779.6 → NP_495180.2  Vacuolar protein sorting-associated protein 35 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495180.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1X3T7, Q21053
    Conserved Domains (1) summary
    pfam03635
    Location:14 → 771
    Vps35; Vacuolar protein sorting-associated protein 35
Nucleotide Protein
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