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cgt-3 Ceramide glucosyltransferase 3 [ Caenorhabditis elegans ]

Gene ID: 174001, updated on 2-Nov-2024

Summary

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Official Symbol
cgt-3
Official Full Name
Ceramide glucosyltransferase 3
Primary source
WormBase:WBGene00019127
Locus tag
CELE_F59G1.1
See related
AllianceGenome:WB:WBGene00019127
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ceramide glucosyltransferase activity. Involved in several processes, including glucosylceramide biosynthetic process; regulation of mesodermal cell fate specification; and regulation of protein localization to basolateral plasma membrane. Located in plasma membrane. Is expressed in several structures, including germ line; head mesodermal cell; hypodermis; pharynx; and rectum. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cgt-3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (5911324..5916910)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Vacuolar protein sorting-associated protein 35 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Frataxin, mitochondrial Neighboring gene Tyrosine-protein phosphatase non-receptor type ptp-2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The impact of C. elegans ceramide glucosyltransferase enzymes on the beneficial effects of B. subtilis lifespan. Arvin CL, et al. MicroPubl Biol, 2023. PMID 37090153, Free PMC Article
  2. Glucosylceramide synthase and glycosphingolipid synthesis. Ichikawa S, et al. Trends Cell Biol, 1998 May. PMID 9695839
  3. Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells. Marza E, et al. J Cell Sci, 2009 Mar 15. PMID 19240113, Free PMC Article
  4. Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division. Nomura KH, et al. Glycobiology, 2011 Jun. PMID 21325339
  5. Targeted lipidomics reveals a novel role for glucosylceramides in glucose response. Xatse MA, et al. J Lipid Res, 2023 Jul. PMID 37245562, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Animals lacking CGT do not synthesize glycosphingolipids, arrest growth at the first larval stage, and display defects in a subset of cells in their digestive tract.
    Title: Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ceramide glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucosylceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucosylceramide biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mesodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mesodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization to basolateral plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ceramide glucosyltransferase 3
NP_001367789.1
  • Confirmed by transcript evidence
NP_495181.2
  • Confirmed by transcript evidence
NP_495182.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5911324..5916910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062780.6 → NP_495181.2  Ceramide glucosyltransferase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495181.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21054
    Conserved Domains (2) summary
    TIGR03472
    Location:119 → 467
    HpnI; hopanoid biosynthesis associated glycosyl transferase protein HpnI
    cd02520
    Location:126 → 357
    Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis

  2. NM_062781.6 → NP_495182.2  Ceramide glucosyltransferase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495182.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EET1, G5EGR9, Q21054, Q8T3D8
    Conserved Domains (2) summary
    TIGR03472
    Location:108 → 456
    HpnI; hopanoid biosynthesis associated glycosyl transferase protein HpnI
    cd02520
    Location:115 → 346
    Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis

  3. NM_001381440.1 → NP_001367789.1  Ceramide glucosyltransferase 3 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd02520
    Location:48 → 279
    Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis

RNA

  1. NR_151564.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21054.2

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