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egl-44 TEA domain-containing protein;Transcription enhancer factor-like protein egl-44 [ Caenorhabditis elegans ]

Gene ID: 174005, updated on 2-Nov-2024

Summary

Official Symbol
egl-44
Official Full Name
TEA domain-containing protein;Transcription enhancer factor-like protein egl-44
Primary source
WormBase:WBGene00001208
Locus tag
CELE_F28B12.2
See related
AllianceGenome:WB:WBGene00001208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator binding activity. Involved in several processes, including generation of neurons; positive regulation of exit from mitosis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including anterior hypodermis; body wall musculature; ganglia; neurons; and pharynx. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to several human genes including TEAD2 (TEA domain transcription factor 2) and TEAD4 (TEA domain transcription factor 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See egl-44 in Genome Data Viewer
Location:
chromosome: II
Exon count:
11
Sequence:
Chromosome: II; NC_003280.10 (5928830..5940830)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase VRK1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in asymmetric neuroblast division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in male mating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
TEA domain-containing protein;Transcription enhancer factor-like protein egl-44
NP_001343765.1
  • Confirmed by transcript evidence
NP_001343766.1
  • Confirmed by transcript evidence
NP_001343767.1
  • Confirmed by transcript evidence
NP_001343768.1
  • Confirmed by transcript evidence
NP_001367307.1
  • Confirmed by transcript evidence
NP_001368664.1
  • Confirmed by transcript evidence
NP_001370297.1
  • Confirmed by transcript evidence
NP_495186.3
  • Confirmed by transcript evidence
NP_741006.3
  • Confirmed by transcript evidence
NP_741007.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5928830..5940830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356848.3NP_001343765.1  TEA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3H3
    Conserved Domains (2) summary
    smart00426
    Location:89156
    TEA; TEA domain
    pfam17725
    Location:287483
    YBD; YAP binding domain
  2. NM_001356849.3NP_001343766.1  TEA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3C4
    Conserved Domains (2) summary
    smart00426
    Location:89156
    TEA; TEA domain
    pfam17725
    Location:280476
    YBD; YAP binding domain
  3. NM_171850.7NP_741007.2  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741007.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D7SFJ5, D7SFJ6, D7SFJ7, D7SFJ8, D7SFJ9, Q19849, Q86NH3, Q86NH4, Q86NH5, Q86NH6, Q95QI4, Q9GT31
    Conserved Domains (1) summary
    smart00426
    Location:90157
    TEA; TEA domain
  4. NM_001356850.3NP_001343767.1  TEA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C2P8
    Conserved Domains (2) summary
    smart00426
    Location:90157
    TEA; TEA domain
    pfam17725
    Location:288484
    YBD; YAP binding domain
  5. NM_171007.6NP_741006.3  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741006.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19849
    Conserved Domains (1) summary
    smart00426
    Location:75142
    TEA; TEA domain
  6. NM_062785.6NP_495186.3  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495186.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19849
    Conserved Domains (1) summary
    smart00426
    Location:75142
    TEA; TEA domain
  7. NM_001381441.3NP_001367307.1  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    smart00426
    Location:3299
    TEA; TEA domain
    pfam17725
    Location:230426
    YBD; YAP binding domain
  8. NM_001381442.1NP_001368664.1  TEA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C333
    Conserved Domains (2) summary
    smart00426
    Location:3299
    TEA; TEA domain
    pfam17725
    Location:223419
    YBD; YAP binding domain
  9. NM_001383853.2NP_001370297.1  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    smart00426
    Location:1582
    TEA; TEA domain
    pfam17725
    Location:206402
    YBD; YAP binding domain
  10. NM_001356852.4NP_001343768.1  TEA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C2W1
    Conserved Domains (2) summary
    smart00426
    Location:1582
    TEA; TEA domain
    pfam17725
    Location:213409
    YBD; YAP binding domain