U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

egl-44 TEA domain-containing protein;Transcription enhancer factor-like protein egl-44 [ Caenorhabditis elegans ]

Gene ID: 174005, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
egl-44
Official Full Name
TEA domain-containing protein;Transcription enhancer factor-like protein egl-44
Primary source
WormBase:WBGene00001208
Locus tag
CELE_F28B12.2
See related
AllianceGenome:WB:WBGene00001208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator binding activity. Involved in several processes, including generation of neurons; positive regulation of exit from mitosis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including anterior hypodermis; body wall musculature; ganglia; neurons; and pharynx. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to several human genes including TEAD2 (TEA domain transcription factor 2) and TEAD4 (TEA domain transcription factor 4). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See egl-44 in Genome Data Viewer
Location:
chromosome: II
Exon count:
11
Sequence:
Chromosome: II; NC_003280.10 (5928830..5940830)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase VRK1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. YAP in epithelium senses gut barrier loss to deploy defenses against pathogens. Ma YC, et al. PLoS Pathog, 2020 Aug. PMID 32857822, Free PMC Article
  2. Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans. Wu J, et al. Genes Dev, 2001 Mar 15. PMID 11274062, Free PMC Article
  3. Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans. Smith CJ, et al. Dev Biol, 2010 Sep 1. PMID 20537990, Free PMC Article
  4. Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron. O'Brien BMJ, et al. Dev Biol, 2017 Dec 15. PMID 29031632, Free PMC Article
  5. Shared gene expression in distinct neurons expressing common selector genes. Topalidou I, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22087002, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in asymmetric neuroblast division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in male mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TEA domain-containing protein;Transcription enhancer factor-like protein egl-44
NP_001343765.1
  • Confirmed by transcript evidence
NP_001343766.1
  • Confirmed by transcript evidence
NP_001343767.1
  • Confirmed by transcript evidence
NP_001343768.1
  • Confirmed by transcript evidence
NP_001367307.1
  • Confirmed by transcript evidence
NP_001368664.1
  • Confirmed by transcript evidence
NP_001370297.1
  • Confirmed by transcript evidence
NP_495186.3
  • Confirmed by transcript evidence
NP_741006.3
  • Confirmed by transcript evidence
NP_741007.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5928830..5940830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356848.3 → NP_001343765.1  TEA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3H3
    Conserved Domains (2) summary
    smart00426
    Location:89 → 156
    TEA; TEA domain
    pfam17725
    Location:287 → 483
    YBD; YAP binding domain

  2. NM_001356849.3 → NP_001343766.1  TEA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3C4
    Conserved Domains (2) summary
    smart00426
    Location:89 → 156
    TEA; TEA domain
    pfam17725
    Location:280 → 476
    YBD; YAP binding domain

  3. NM_171850.7 → NP_741007.2  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741007.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D7SFJ5, D7SFJ6, D7SFJ7, D7SFJ8, D7SFJ9, Q19849, Q86NH3, Q86NH4, Q86NH5, Q86NH6, Q95QI4, Q9GT31
    Conserved Domains (1) summary
    smart00426
    Location:90 → 157
    TEA; TEA domain

  4. NM_001356850.3 → NP_001343767.1  TEA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C2P8
    Conserved Domains (2) summary
    smart00426
    Location:90 → 157
    TEA; TEA domain
    pfam17725
    Location:288 → 484
    YBD; YAP binding domain

  5. NM_171007.6 → NP_741006.3  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741006.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19849
    Conserved Domains (1) summary
    smart00426
    Location:75 → 142
    TEA; TEA domain

  6. NM_062785.6 → NP_495186.3  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495186.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19849
    Conserved Domains (1) summary
    smart00426
    Location:75 → 142
    TEA; TEA domain

  7. NM_001381441.3 → NP_001367307.1  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    smart00426
    Location:32 → 99
    TEA; TEA domain
    pfam17725
    Location:230 → 426
    YBD; YAP binding domain

  8. NM_001381442.1 → NP_001368664.1  TEA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C333
    Conserved Domains (2) summary
    smart00426
    Location:32 → 99
    TEA; TEA domain
    pfam17725
    Location:223 → 419
    YBD; YAP binding domain

  9. NM_001383853.2 → NP_001370297.1  Transcription enhancer factor-like protein egl-44 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    smart00426
    Location:15 → 82
    TEA; TEA domain
    pfam17725
    Location:206 → 402
    YBD; YAP binding domain

  10. NM_001356852.4 → NP_001343768.1  TEA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C2W1
    Conserved Domains (2) summary
    smart00426
    Location:15 → 82
    TEA; TEA domain
    pfam17725
    Location:213 → 409
    YBD; YAP binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19849.4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous