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set-4 Histone-lysine N-methyltransferase Suv4-20 [ Caenorhabditis elegans ]

Gene ID: 174045, updated on 2-Nov-2024

Summary

Official Symbol
set-4
Official Full Name
Histone-lysine N-methyltransferase Suv4-20
Primary source
WormBase:WBGene00016313
Locus tag
CELE_C32D5.5
See related
AllianceGenome:WB:WBGene00016313
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone H4K20me methyltransferase activity. Involved in determination of adult lifespan. Predicted to be located in chromosome and nucleus. Is expressed in several structures, including germ line; hypodermis; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 51. Orthologous to human KMT5B (lysine methyltransferase 5B) and KMT5C (lysine methyltransferase 5C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See set-4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (6329838..6331341, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase receptor sma-6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TeTratriCopeptide repeat domain protein related Neighboring gene DUF2934 domain-containing protein

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone H4K20me methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Histone-lysine N-methyltransferase Suv4-20
NP_495272.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6329838..6331341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062871.6NP_495272.1  Histone-lysine N-methyltransferase Suv4-20 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495272.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09265
    Conserved Domains (1) summary
    smart00317
    Location:129244
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain