ani-2 Anillin-like protein 2 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: ani-2
Official Full Name: Anillin-like protein 2
Primary source: WormBase:WBGene00019608
Locus tag: CELE_K10B2.5
See related: AllianceGenome:WB:WBGene00019608
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including gonad development; ovulation; and syncytium formation. Located in cytoplasm. Is expressed in germ line. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin, actin binding protein). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ani-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 12

Sequence:: Chromosome: II; NC_003280.10 (6361159..6365367, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANI-2 promotes germ cell syncytial organization and allows for compensation of the mechanical stress associated with oogenesis.
Title: C. elegans Anillin proteins regulate intercellular bridge stability and germline syncytial organization.
These results indicate that PAR-4 controls C. elegans embryonic polarity by regulating the activity of anillin family scaffold proteins, thus enabling turnover of cortical myosin and efficient actomyosin contractility.
Title: PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

K10B2.3 (e-PCR)
- UniSTS:311519

K10B2.5 (e-PCR)
- UniSTS:311520

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in actomyosin contractile ring assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organismal reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septin ring organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in syncytium formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actomyosin contractile ring	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Anillin-like protein 2

NP_495282.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6361159..6365367 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062881.4 → NP_495282.1 Anillin-like protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495282.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09994

Conserved Domains (3) summary

cd01263
Location:892 → 1008

PH_anillin; Anillin Pleckstrin homology (PH) domain

pfam00169
Location:893 → 1004

PH; PH domain

pfam08174
Location:712 → 861

Anillin; Cell division protein anillin