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nhr-22 Nuclear hormone receptor family member nhr-22 [ Caenorhabditis elegans ]

Gene ID: 174066, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-22
Official Full Name
Nuclear hormone receptor family member nhr-22
Primary source
WormBase:WBGene00003621
Locus tag
CELE_K06A1.4
See related
AllianceGenome:WB:WBGene00003621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in cytosol and nucleus. Is expressed in several structures, including coelomocyte; intestine; neurons; non-striated muscle; and rectal gland cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-22 in Genome Data Viewer
Location:
chromosome: II
Exon count:
10
Sequence:
Chromosome: II; NC_003280.10 (6446195..6449792, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ZP domain-containing protein Neighboring gene Serpentine Receptor, class Z;Transmembrane protein Neighboring gene Autophagic-related protein 16.2 Neighboring gene Transcription factor aptf-1 Neighboring gene Diacylglycerol kinase;Putative diacylglycerol kinase K06A1.6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and function of members of a divergent nuclear receptor family in Caenorhabditis elegans. Miyabayashi T, et al. Dev Biol, 1999 Nov 15. PMID 10545240
  2. Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships. Pathare PP, et al. PLoS Genet, 2012. PMID 22511885, Free PMC Article
  3. Proteins interacting with Caenorhabditis elegans Galpha subunits. Cuppen E, et al. Comp Funct Genomics, 2003. PMID 18629017, Free PMC Article
  4. Protein interaction mapping in C. elegans using proteins involved in vulval development. Walhout AJ, et al. Science, 2000 Jan 7. PMID 10615043
  5. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-22
NP_495298.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6446195..6449792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062897.7 → NP_495298.1  Nuclear hormone receptor family member nhr-22 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495298.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09587, Q9GTI4, Q9GTI5
    Conserved Domains (2) summary
    smart00399
    Location:96 → 169
    ZnF_C4; c4 zinc finger in nuclear hormone receptors
    smart00430
    Location:366 → 547
    HOLI; Ligand binding domain of hormone receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09587.2

Gene LinkOut

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