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dgk-5 Diacylglycerol kinase;Putative diacylglycerol kinase K06A1.6 [ Caenorhabditis elegans ]

Gene ID: 174068, updated on 2-Nov-2024

Summary

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Official Symbol
dgk-5
Official Full Name
Diacylglycerol kinase;Putative diacylglycerol kinase K06A1.6
Primary source
WormBase:WBGene00019428
Locus tag
CELE_K06A1.6
See related
AllianceGenome:WB:WBGene00019428
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in diacylglycerol metabolic process; intracellular signal transduction; and phosphatidic acid biosynthetic process. Predicted to be active in membrane. Orthologous to human DGKI (diacylglycerol kinase iota) and DGKZ (diacylglycerol kinase zeta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dgk-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
21
Sequence:
Chromosome: II; NC_003280.10 (6456512..6471085, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-22 Neighboring gene Autophagic-related protein 16.2 Neighboring gene Transcription factor aptf-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Degenerin-like protein del-10 Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans. Lin YH, et al. Aging Cell, 2014 Aug. PMID 24889782, Free PMC Article
  2. Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans. Jushaj A, et al. Biogerontology, 2023 Apr. PMID 36662373
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Diacylglycerol kinase;Putative diacylglycerol kinase K06A1.6
NP_001355399.1
  • Confirmed by transcript evidence
NP_001355400.1
  • Confirmed by transcript evidence
NP_001355416.1
  • Confirmed by transcript evidence
NP_001355417.1
  • Confirmed by transcript evidence
NP_495301.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6456512..6471085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001368593.5 → NP_001355400.1  Diacylglycerol kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1DQ66
    Conserved Domains (3) summary
    smart00045
    Location:621 → 774
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:469 → 593
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cl00040
    Location:351 → 410
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  2. NM_001368594.2 → NP_001355399.1  Diacylglycerol kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E8R6
    Conserved Domains (3) summary
    smart00045
    Location:576 → 729
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:424 → 548
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cl00040
    Location:306 → 365
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  3. NM_062900.4 → NP_495301.1  Putative diacylglycerol kinase K06A1.6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495301.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09588, Q10024
    Conserved Domains (3) summary
    smart00045
    Location:572 → 725
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:420 → 544
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam00130
    Location:302 → 363
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  4. NM_001368596.3 → NP_001355417.1  Diacylglycerol kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E3M2
    Conserved Domains (4) summary
    smart00045
    Location:785 → 938
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:633 → 757
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    pfam17061
    Location:215 → 381
    PARM
    pfam00130
    Location:515 → 574
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  5. NM_001368595.4 → NP_001355416.1  Diacylglycerol kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1DVJ7
    Conserved Domains (3) summary
    smart00045
    Location:510 → 663
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:358 → 482
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cl00040
    Location:240 → 299
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10024.2

Gene LinkOut

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