icd-1 Transcription factor BTF3 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: icd-1
Official Full Name: Transcription factor BTF3 homolog
Primary source: WormBase:WBGene00002045
Locus tag: CELE_C56C10.8
See related: AllianceGenome:WB:WBGene00002045
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in embryo development and negative regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including germ line; intestine; pharynx; preanal ganglion; and somatic nervous system. Orthologous to human BTF3 (basic transcription factor 3) and BTF3L4 (basic transcription factor 3 like 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See icd-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (6587577..6588655, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caenorhabditis elegans inhibitor of cell death-1 (ICD-1) is necessary and sufficient to prevent apoptosis [ICD-1]
Title: Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C56C10.8 (e-PCR)
- UniSTS:316450

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of nascent polypeptide-associated complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription factor BTF3 homolog

NP_495336.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6587577..6588655 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062935.10 → NP_495336.1 Transcription factor BTF3 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495336.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18885

Conserved Domains (1) summary

pfam01849
Location:45 → 96

NAC; NAC domain