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gyf-1 GYF domain-containing protein gyf-1 [ Caenorhabditis elegans ]

Gene ID: 174103, updated on 2-Nov-2024

Summary

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Official Symbol
gyf-1
Official Full Name
GYF domain-containing protein gyf-1
Primary source
WormBase:WBGene00016002
Locus tag
CELE_C18H9.3
See related
AllianceGenome:WB:WBGene00016002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to several human genes including GIGYF2 (GRB10 interacting GYF protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gyf-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
11
Sequence:
Chromosome: II; NC_003280.10 (6684235..6692729)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene VWFA domain-containing protein Neighboring gene pseudo Neighboring gene Intraflagellar transport protein 74 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development. Mayya VK, et al. Nucleic Acids Res, 2021 May 21. PMID 33758928, Free PMC Article
  2. Autofluorescence as a noninvasive biomarker of senescence and advanced glycation end products in Caenorhabditis elegans. Komura T, et al. NPJ Aging Mech Dis, 2021 Jun 7. PMID 34099724, Free PMC Article
  3. The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity. Snoznik C, et al. Proc Natl Acad Sci U S A, 2021 Oct 5. PMID 34593637, Free PMC Article
  4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development.
    Title: microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GYF domain-containing protein gyf-1
NP_001343744.1
  • Confirmed by transcript evidence
NP_001343745.1
  • Confirmed by transcript evidence
NP_001343746.1
  • Confirmed by transcript evidence
NP_001343747.1
  • Confirmed by transcript evidence
NP_495360.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6684235..6692729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356866.2 → NP_001343745.1  GYF domain-containing protein gyf-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    PTZ00121
    Location:565 → 961
    PTZ00121; MAEBL; Provisional
    smart00444
    Location:457 → 513
    GYF; Contains conserved Gly-Tyr-Phe residues

  2. NM_062959.3 → NP_495360.2  GYF domain-containing protein gyf-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495360.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09237
    Conserved Domains (3) summary
    smart00444
    Location:389 → 445
    GYF; Contains conserved Gly-Tyr-Phe residues
    pfam07926
    Location:507 → 608
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam13863
    Location:516 → 616
    DUF4200; Domain of unknown function (DUF4200)

  3. NM_001356864.3 → NP_001343746.1  GYF domain-containing protein gyf-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A2C9C305, A0A2C9C367, A0A2C9C3A1, A0A2C9C3E9, Q09237, Q09482
    Conserved Domains (2) summary
    PTZ00121
    Location:568 → 964
    PTZ00121; MAEBL; Provisional
    smart00444
    Location:460 → 516
    GYF; Contains conserved Gly-Tyr-Phe residues

  4. NM_001356865.3 → NP_001343744.1  GYF domain-containing protein gyf-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    PTZ00121
    Location:500 → 896
    PTZ00121; MAEBL; Provisional
    smart00444
    Location:392 → 448
    GYF; Contains conserved Gly-Tyr-Phe residues

  5. NM_001356867.3 → NP_001343747.1  GYF domain-containing protein gyf-1 [Caenorhabditis elegans]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09237.4

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