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malt-1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [ Caenorhabditis elegans ]

Gene ID: 174135, updated on 19-Jun-2024

Summary

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Gene symbol
malt-1
Gene description
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Locus tag
CELE_F22D3.6
See related
AllianceGenome:WB:WBGene00017702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Is expressed in RMG and oxygen sensory neurons. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See malt-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
14
Sequence:
Chromosome: II; NC_003280.10 (6947855..6951300, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Folliculin;Folliculin DENN domain-containing protein;UDENN FLCN/SMCR8-type domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Homeobox protein ceh-38;One cut domain family member Neighboring gene Sex-determining transformer protein 2 Neighboring gene Translation initiation factor eIF2B subunit gamma

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. Flynn SM, et al. Nat Commun, 2020 Apr 29. PMID 32350248, Free PMC Article
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MALT1 has an ancient role modulating neural circuit function downstream of IL-17 to remodel physiology and behavior.
    Title: MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
NP_495424.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6947855..6951300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063023.9 → NP_495424.2  Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495424.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG87
    Conserved Domains (2) summary
    pfam00656
    Location:252 → 481
    Peptidase_C14; Caspase domain
    cl11960
    Location:122 → 182
    Ig; Immunoglobulin domain
Nucleotide Protein
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