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sqv-7 UDP-sugar transporter sqv-7 [ Caenorhabditis elegans ]

Gene ID: 174145, updated on 2-Nov-2024

Summary

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Official Symbol
sqv-7
Official Full Name
UDP-sugar transporter sqv-7
Primary source
WormBase:WBGene00005025
Locus tag
CELE_C52E12.3
See related
AllianceGenome:WB:WBGene00005025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables UDP-N-acetylgalactosamine transmembrane transporter activity; UDP-galactose transmembrane transporter activity; and UDP-glucuronic acid transmembrane transporter activity. Involved in several processes, including egg-laying behavior; proteoglycan biosynthetic process; and pyrimidine nucleotide-sugar transmembrane transport. Located in cytoplasm. Is expressed in several structures, including hermaphrodite distal tip cell; intestine; nervous system; oocyte; and vulval cell. Human ortholog(s) of this gene implicated in schneckenbecken dysplasia. Orthologous to several human genes including SLC35D1 (solute carrier family 35 member D1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sqv-7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (7010811..7012690, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein unc-104 Neighboring gene tRNA-Ala Neighboring gene tRNA-Thr Neighboring gene ncRNA Neighboring gene Lateral Signaling Target Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactose. Berninsone P, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11259660, Free PMC Article
  2. An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state. Pedersen ME, et al. Science, 2013 Sep 20. PMID 24052309
  3. sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis. Bulik DA, et al. Proc Natl Acad Sci U S A, 2000 Sep 26. PMID 11005858, Free PMC Article
  4. Functional redundancy between two Caenorhabditis elegans nucleotide sugar transporters with a novel transport mechanism. Caffaro CE, et al. J Biol Chem, 2007 Sep 21. PMID 17652078
  5. The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development. Hwang HY, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12391314, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables UDP-N-acetylgalactosamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylgalactosamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-N-acetylglucosamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-galactose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucuronic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucuronic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylgalactosamine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP-N-acetylglucosamine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in UDP-galactose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP-glucuronic acid transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chondroitin sulfate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-sugar transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of distal tip cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-sugar transporter sqv-7
NP_495436.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7010811..7012690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063035.6 → NP_495436.1  UDP-sugar transporter sqv-7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495436.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18779
    Conserved Domains (1) summary
    pfam03151
    Location:21 → 299
    TPT; Triose-phosphate Transporter family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18779.1

Gene LinkOut

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