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lst-6 Lateral Signaling Target [ Caenorhabditis elegans ]

Gene ID: 174146, updated on 2-Nov-2024

Summary

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Official Symbol
lst-6
Official Full Name
Lateral Signaling Target
Primary source
WormBase:WBGene00016889
Locus tag
CELE_C52E12.4
See related
AllianceGenome:WB:WBGene00016889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be located in membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 49. Orthologous to human DENND5A (DENN domain containing 5A) and DENND5B (DENN domain containing 5B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lst-6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
20
Sequence:
Chromosome: II; NC_003280.10 (7012780..7022509, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein unc-104 Neighboring gene tRNA-Thr Neighboring gene ncRNA Neighboring gene UDP-sugar transporter sqv-7 Neighboring gene C2H2-type domain-containing protein Neighboring gene RING-type E3 ubiquitin transferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Lateral Signaling Target
NP_001367509.1
  • Product from WormBase gene class lst;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7012780..7022509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381485.3 → NP_001367509.1  Lateral Signaling Target [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18780
    Conserved Domains (5) summary
    smart00801
    Location:537 → 614
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00593
    Location:1064 → 1127
    RUN; domain involved in Ras-like GTPase signaling
    smart00799
    Location:199 → 381
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:11 → 123
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:1134 → 1244
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
Nucleotide Protein
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