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znf-598 RING-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

Gene ID: 174148, updated on 2-Nov-2024

Summary

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Official Symbol
znf-598
Official Full Name
RING-type E3 ubiquitin transferase
Primary source
WormBase:WBGene00016888
Locus tag
CELE_C52E12.1
See related
AllianceGenome:WB:WBGene00016888
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ribosome binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and rescue of stalled ribosome. Predicted to be located in cytoplasm. Orthologous to human ZNF598 (zinc finger protein 598, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See znf-598 in Genome Data Viewer
Location:
chromosome: II
Exon count:
15
Sequence:
Chromosome: II; NC_003280.10 (7025802..7030156)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Lateral Signaling Target Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitination of stalled ribosomes enables mRNA decay via HBS-1 and NONU-1 in vivo. Monem PC, et al. PLoS Genet, 2023 Jan. PMID 36626369, Free PMC Article
  2. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
  3. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
  4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rescue of stalled ribosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING-type E3 ubiquitin transferase
NP_001362178.1
  • Confirmed by transcript evidence
NP_495439.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7025802..7030156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001375249.1 → NP_001362178.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5K1ICF1
    Conserved Domains (2) summary
    COG5236
    Location:47 → 356
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00020
    Location:183 → 210
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_063038.6 → NP_495439.2  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495439.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18782
    Conserved Domains (2) summary
    COG5236
    Location:47 → 356
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00020
    Location:183 → 210
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
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