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mmaa-1 Methylmalonic aciduria type A homolog, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 174164, updated on 2-Nov-2024

Summary

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Official Symbol
mmaa-1
Official Full Name
Methylmalonic aciduria type A homolog, mitochondrial
Primary source
WormBase:WBGene00020169
Locus tag
CELE_T02G5.13
See related
AllianceGenome:WB:WBGene00020169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activity. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Used to study methylmalonic acidemia. Human ortholog(s) of this gene implicated in methylmalonic acidemia cblA type. Orthologous to human MMAA (metabolism of cobalamin associated A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mmaa-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003280.10 (7099583..7101165, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene F-box domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene DUF3402 domain-containing protein;Far11/STRP C-terminal domain-containing protein Neighboring gene Large ribosomal subunit protein eL33

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A dodecylamine derivative of cyanocobalamin potently inhibits the activities of cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase of Caenorhabditis elegans. Bito T, et al. FEBS Open Bio, 2014. PMID 25161880, Free PMC Article
  2. Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism. Chandler RJ, et al. Mol Genet Metab, 2006 Sep-Oct. PMID 16843692, Free PMC Article
  3. Biochemistry, function, and deficiency of vitamin B12 in Caenorhabditis elegans. Bito T, et al. Exp Biol Med (Maywood), 2016 Sep. PMID 27486161, Free PMC Article
  4. Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation. Baytek G, et al. Biotechniques, 2022 May. PMID 35297663
  5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Methylmalonic aciduria type A homolog, mitochondrial
NP_001022302.1
  • Confirmed by transcript evidence
NP_001379869.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7099583..7101165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393114.1 → NP_001379869.1  Methylmalonic aciduria type A homolog, mitochondrial [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl38936
    Location:24 → 297
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001027131.7 → NP_001022302.1  Methylmalonic aciduria type A homolog, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022302.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22111, Q6AHP0
    Conserved Domains (2) summary
    smart00382
    Location:127 → 227
    AAA; ATPases associated with a variety of cellular activities
    cl21455
    Location:64 → 398
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22111.2

Gene LinkOut

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