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fust-1 RNA-binding protein FUS [ Caenorhabditis elegans ]

Gene ID: 174175, updated on 2-Nov-2024

Summary

Official Symbol
fust-1
Official Full Name
RNA-binding protein FUS
Primary source
WormBase:WBGene00016173
Locus tag
CELE_C27H5.3
See related
AllianceGenome:WB:WBGene00016173
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including gonad; head; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in connective tissue cancer (multiple); essential tremor 4; and neurodegenerative disease (multiple). Orthologous to several human genes including FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See fust-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (7152581..7155476)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Zinc finger PHD-type domain-containing protein Neighboring gene TAR DNA-binding protein 43 N-terminal domain-containing protein Neighboring gene Ferrochelatase

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RNA-binding protein FUS
NP_001368629.1
  • Confirmed by transcript evidence
NP_495483.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7152581..7155476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381492.1NP_001368629.1  RNA-binding protein FUS [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYQ6
    Conserved Domains (2) summary
    smart00547
    Location:340363
    ZnF_RBZ; Zinc finger domain
    cd12280
    Location:145226
    RRM_FET; RNA recognition motif (RRM) found in the FET family of RNA-binding proteins
  2. NM_063082.7NP_495483.1  RNA-binding protein FUS [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495483.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18265
    Conserved Domains (3) summary
    smart00547
    Location:398421
    ZnF_RBZ; Zinc finger domain
    COG0724
    Location:202290
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12280
    Location:203284
    RRM_FET; RNA recognition motif in the FET family of RNA-binding proteins