U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ctsa-3.1 Serine carboxypeptidase ctsa-3.1 [ Caenorhabditis elegans ]

Gene ID: 174189, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ctsa-3.1
Official Full Name
Serine carboxypeptidase ctsa-3.1
Primary source
WormBase:WBGene00017969
Locus tag
CELE_F32A5.3
See related
AllianceGenome:WB:WBGene00017969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Located in membrane raft. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ctsa-3.1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (7232853..7235920)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Chloride channel protein;Chloride channel protein clh-3 Neighboring gene Uncharacterized protein Neighboring gene Aquaporin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein Neighboring gene Peroxisomal membrane protein PEX13

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. Rao W, et al. J Proteomics, 2011 Feb 1. PMID 21070894
  2. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  3. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane raft HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Serine carboxypeptidase ctsa-3.1
NP_495509.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7232853..7235920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063108.8 → NP_495509.1  Serine carboxypeptidase ctsa-3.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495509.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52716
    Conserved Domains (1) summary
    pfam00450
    Location:28 → 526
    Peptidase_S10; Serine carboxypeptidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52716.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.