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nhr-21 NR LBD domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174202, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-21
Official Full Name
NR LBD domain-containing protein
Primary source
WormBase:WBGene00003620
Locus tag
CELE_F21D12.1
See related
AllianceGenome:WB:WBGene00003620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in spermatheca. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-21 in Genome Data Viewer
Location:
chromosome: II
Exon count:
10
Sequence:
Chromosome: II; NC_003280.10 (7339229..7349133)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Amino acid transporter transmembrane domain-containing protein Neighboring gene Paired domain-containing protein Neighboring gene Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D Neighboring gene ABC-type antigen peptide transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
  2. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NR LBD domain-containing protein
NP_001022100.1
  • Confirmed by transcript evidence
NP_001022101.1
  • Partially confirmed by transcript evidence
NP_001022102.1
  • Confirmed by transcript evidence
NP_001022103.1
  • Confirmed by transcript evidence
NP_001040766.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7339229..7349133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026931.7 → NP_001022102.1  NR LBD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022102.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZU2, Q9UAN6
    Conserved Domains (2) summary
    cd06157
    Location:236 → 406
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    cd06960
    Location:22 → 97
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  2. NM_001047301.4 → NP_001040766.1  NR LBD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040766.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZU4, Q9UAN6
    Conserved Domains (2) summary
    cd06157
    Location:244 → 416
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    cd06960
    Location:30 → 105
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  3. NM_001026929.5 → NP_001022100.1  NR LBD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022100.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZU1, Q9UAN6
    Conserved Domains (2) summary
    cd06157
    Location:242 → 414
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    cd06960
    Location:30 → 105
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  4. NM_001026932.5 → NP_001022103.1  NR LBD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022103.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZU3, Q9UAN6
    Conserved Domains (2) summary
    cd06157
    Location:242 → 412
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    cd06960
    Location:30 → 105
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  5. NM_001026930.4 → NP_001022101.1  NR LBD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022101.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBL9, Q9UAN6
    Conserved Domains (2) summary
    cd06157
    Location:196 → 366
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    cl02596
    Location:27 → 57
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
Nucleotide Protein
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