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rpa-1 putative replication factor A 73 kDa subunit [ Caenorhabditis elegans ]

Gene ID: 174238, updated on 2-Nov-2024

Summary

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Official Symbol
rpa-1
Official Full Name
putative replication factor A 73 kDa subunit
Primary source
WormBase:WBGene00017546
Locus tag
CELE_F18A1.5
See related
AllianceGenome:WB:WBGene00017546
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables enzyme binding activity. Involved in positive regulation of nematode male tail tip morphogenesis. Located in nucleoplasm. Is expressed in germ line and pharynx. Orthologous to human RPA1 (replication protein A1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rpa-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (7664582..7667110)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ALS/FTD Associated gene homolog Neighboring gene Chondroitin proteoglycan 4 domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene BED-type domain-containing protein;LIn-26 Related Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aging Negatively Impacts DNA Repair and Bivalent Formation in the C. elegans Germ Line. Raices M, et al. Front Cell Dev Biol, 2021. PMID 34422819, Free PMC Article
  2. Non-transcriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis. Daitoku H, et al. Mol Cell Biol, 2016 Nov. PMID 27550812, Free PMC Article
  3. Differential RPA-1 and RAD-51 recruitment in vivo throughout the C. elegans germline, as revealed by laser microirradiation. Koury E, et al. Nucleic Acids Res, 2018 Jan 25. PMID 29244155, Free PMC Article
  4. Molecular characteristics of reiterative DNA unwinding by the Caenorhabditis elegans RecQ helicase. Choi S, et al. Nucleic Acids Res, 2019 Oct 10. PMID 31435650, Free PMC Article
  5. ssDNA reeling is an intermediate step in the reiterative DNA unwinding activity of the WRN-1 helicase. Le ST, et al. J Biol Chem, 2023 Sep. PMID 37495105, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we found that Caenorhabditis elegans replication protein A, a single-stranded DNA binding protein, suppresses the reiterative behavior of HIM-6 and induces unidirectional, processive unwinding, possibly through a direct interaction between the proteins.
    Title: Molecular characteristics of reiterative DNA unwinding by the Caenorhabditis elegans RecQ helicase.
  2. Data show that replication factor A (RPA-1) and DNA repair protein RAD51 (RAD-51) colocalization for hours post-microirradiation throughout the germline.
    Title: Differential RPA-1 and RAD-51 recruitment in vivo throughout the C. elegans germline, as revealed by laser microirradiation.
  3. analysis of physical and functional interactions of Caenorhabditis elegans WRN-1 helicase with RPA-1
    Title: Physical and functional interactions of Caenorhabditis elegans WRN-1 helicase with RPA-1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables single-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA replication factor A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor A complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative replication factor A 73 kDa subunit
NP_495606.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7664582..7667110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063205.7 → NP_495606.1  putative replication factor A 73 kDa subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495606.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19537
    Conserved Domains (4) summary
    cd04474
    Location:225 → 325
    RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
    cd04475
    Location:353 → 455
    RPA1_DBD_B; RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
    TIGR00617
    Location:12 → 648
    rpa1; replication factor-a protein 1 (rpa1)
    pfam08646
    Location:498 → 642
    Rep_fac-A_C; Replication factor-A C terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19537.1

Gene LinkOut

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