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sds-22 Protein phosphatase 1 regulatory subunit SDS22 homolog [ Caenorhabditis elegans ]

Gene ID: 174266, updated on 2-Nov-2024

Summary

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Official Symbol
sds-22
Official Full Name
Protein phosphatase 1 regulatory subunit SDS22 homolog
Primary source
WormBase:WBGene00011637
Locus tag
CELE_T09A5.9
See related
AllianceGenome:WB:WBGene00011637
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in negative regulation of centriole replication. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human PPP1R7 (protein phosphatase 1 regulatory subunit 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sds-22 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (7858401..7859753)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Chromo domain-containing protein cec-3 Neighboring gene Small integral membrane protein 26 Neighboring gene Spindle apparatus protein lin-5 Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. Peel N, et al. PLoS Genet, 2017 Jan. PMID 28103229, Free PMC Article
  2. IGLR-2, a Leucine-Rich Repeat Domain Containing Protein, Is Required for the Host Defense in Caenorhabditis elegans. Kuo CJ, et al. Front Immunol, 2020. PMID 33329523, Free PMC Article
  3. Suppressors of zyg-1 define regulators of centrosome duplication and nuclear association in Caenorhabditis elegans. Kemp CA, et al. Genetics, 2007 May. PMID 17446307, Free PMC Article
  4. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
  5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in negative regulation of centriole replication IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein phosphatase 1 regulatory subunit SDS22 homolog
NP_495653.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7858401..7859753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063252.6 → NP_495653.1  Protein phosphatase 1 regulatory subunit SDS22 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495653.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P45969
    Conserved Domains (3) summary
    sd00033
    Location:40 → 59
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:104 → 144
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:82 → 137
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45969.1

Gene LinkOut

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