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ptc-1 Protein patched homolog 1;SSD domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174274, updated on 2-Nov-2024

Summary

Official Symbol
ptc-1
Official Full Name
Protein patched homolog 1;SSD domain-containing protein
Primary source
WormBase:WBGene00004208
Locus tag
CELE_ZK675.1
See related
AllianceGenome:WB:WBGene00004208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in molting cycle. Located in plasma membrane. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in carcinoma (multiple); holoprosencephaly (multiple); medulloblastoma; nevoid basal cell carcinoma syndrome (multiple); and stomach cancer. Orthologous to human PTCH1 (patched 1) and PTCH2 (patched 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See ptc-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (7893222..7900515)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA repair protein REV1 Neighboring gene Bestrophin homolog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hedgehog family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hedgehog receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables smoothened binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in molting cycle, collagen and cuticulin-based cuticle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Protein patched homolog 1;SSD domain-containing protein
NP_001360447.1
  • Confirmed by transcript evidence
NP_495662.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7893222..7900515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373748.3NP_001360447.1  SSD domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3P6N6C5
    Conserved Domains (1) summary
    cl25655
    Location:11203
    Patched; Patched family
  2. NM_063261.6NP_495662.2  Protein patched homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495662.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09614
    Conserved Domains (2) summary
    TIGR00918
    Location:831345
    2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family
    cl21543
    Location:684832
    MMPL; MMPL family