glna-2 Putative glutaminase 2;glutaminase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: glna-2
Official Full Name: Putative glutaminase 2;glutaminase
Primary source: WormBase:WBGene00008435
Locus tag: CELE_DH11.1
See related: AllianceGenome:WB:WBGene00008435
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glutaminase activity. Predicted to be involved in glutamate biosynthetic process and glutamine catabolic process. Predicted to be located in mitochondrion. Is expressed in several structures, including body wall musculature; head neurons; intestine; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to several human genes including GLS (glutaminase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See glna-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (8008634..8011633)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DH11.1 (e-PCR)
- UniSTS:309501

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glutaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutaminase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutamate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Putative glutaminase 2;glutaminase

NP_001305214.1

Confirmed by transcript evidence

NP_001380189.1

Confirmed by transcript evidence

NP_495675.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8008634..8011633

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393130.1 → NP_001380189.1 glutaminase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S4XRH7

Conserved Domains (3) summary

sd00045
Location:254 → 286

ANK; ANK repeat [structural motif]

pfam04960
Location:1 → 197

Glutaminase

pfam12796
Location:227 → 308

Ank_2; Ankyrin repeats (3 copies)
NM_063274.4 → NP_495675.1 Putative glutaminase 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495675.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19013

Conserved Domains (4) summary

cd00204
Location:486 → 567

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam04960
Location:171 → 458

Glutaminase; Glutaminase

pfam13637
Location:484 → 534

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:513 → 545

ANK; ANK repeat [structural motif]
NM_001318285.3 → NP_001305214.1 glutaminase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S4XRA9

Conserved Domains (3) summary

sd00045
Location:98 → 130

ANK; ANK repeat [structural motif]

pfam12796
Location:71 → 152

Ank_2; Ankyrin repeats (3 copies)

cl00907
Location:1 → 43

Glutaminase