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cct-1 T-complex protein 1 subunit alpha [ Caenorhabditis elegans ]

Gene ID: 174318, updated on 2-Nov-2024

Summary

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Official Symbol
cct-1
Official Full Name
T-complex protein 1 subunit alpha
Primary source
WormBase:WBGene00000377
Locus tag
CELE_T05C12.7
See related
AllianceGenome:WB:WBGene00000377
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in nucleus. Part of chaperonin-containing T-complex. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and vulva. Orthologous to human TCP1 (t-complex 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cct-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
5
Sequence:
Chromosome: II; NC_003280.10 (8185443..8187601)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DYnein Light chain (Tctex type) Neighboring gene Segment polarity protein dishevelled homolog mig-5 Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular analysis of Caenorhabditis elegans tcp-1, a gene encoding a chaperonin protein. Leroux MR, et al. Gene, 1995 Apr 24. PMID 7758963
  2. Subunit characterization of the Caenorhabditis elegans chaperonin containing TCP-1 and expression pattern of the gene encoding CCT-1. Leroux MR, et al. Biochem Biophys Res Commun, 1997 Dec 29. PMID 9434769
  3. Characterization of four new tcp-1-related cct genes from the nematode Caenorhabditis elegans. Leroux MR, et al. DNA Cell Biol, 1995 Nov. PMID 7576182
  4. Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans. Lundin VF, et al. Dev Biol, 2008 Jan 1. PMID 18062952
  5. Caenorhabditis elegans chaperonin CCT/TRiC is required for actin and tubulin biogenesis and microvillus formation in intestinal epithelial cells. Saegusa K, et al. Mol Biol Cell, 2014 Oct 15. PMID 25143409, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
T-complex protein 1 subunit alpha
NP_495722.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8185443..8187601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063321.5 → NP_495722.1  T-complex protein 1 subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495722.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41988, Q22228
    Conserved Domains (2) summary
    cd03335
    Location:13 → 538
    TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    TIGR02340
    Location:9 → 543
    chap_CCT_alpha; T-complex protein 1, alpha subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41988.2

Gene LinkOut

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