stc-1 Heat shock 70 kDa protein 13 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: stc-1
Official Full Name: Heat shock 70 kDa protein 13
Primary source: WormBase:WBGene00006059
Locus tag: CELE_F54C9.2
See related: AllianceGenome:WB:WBGene00006059
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity and ATP-dependent protein folding chaperone. Involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum. Is expressed in intestine. Orthologous to human HSPA13 (heat shock protein family A (Hsp70) member 13). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See stc-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (8563709..8566139, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54C9.2 (e-PCR)
- UniSTS:311770

F54C9.3 (e-PCR)
- UniSTS:320989

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in response to topologically incorrect protein	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Heat shock 70 kDa protein 13

NP_495808.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8563709..8566139 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063407.6 → NP_495808.2 Heat shock 70 kDa protein 13 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495808.2

Status: REVIEWED

UniProtKB/TrEMBL

Q20752

Conserved Domains (1) summary

cd10237
Location:13 → 427

HSPA13-like_NBD; Nucleotide-binding domain of human HSPA13 and similar proteins